Targeting viral entry as a strategy for broad-spectrum antivirals
Identifieur interne : 000379 ( Main/Exploration ); précédent : 000378; suivant : 000380Targeting viral entry as a strategy for broad-spectrum antivirals
Auteurs : Michela Mazzon [Royaume-Uni] ; Mark Marsh [Royaume-Uni]Source :
- F1000Research [ 2046-1402 ] ; 2019.
Abstract
The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.
Url:
DOI: 10.12688/f1000research.19694.1
PubMed: 31559009
PubMed Central: 6743247
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting viral entry as a strategy for broad-spectrum antivirals</title><author><name sortKey="Mazzon, Michela" sort="Mazzon, Michela" uniqKey="Mazzon M" first="Michela" last="Mazzon">Michela Mazzon</name><affiliation wicri:level="4"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Marsh, Mark" sort="Marsh, Mark" uniqKey="Marsh M" first="Mark" last="Marsh">Mark Marsh</name><affiliation wicri:level="4"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31559009</idno><idno type="pmc">6743247</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743247</idno><idno type="RBID">PMC:6743247</idno><idno type="doi">10.12688/f1000research.19694.1</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000949</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000949</idno><idno type="wicri:Area/Pmc/Curation">000949</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000949</idno><idno type="wicri:Area/Pmc/Checkpoint">000341</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000341</idno><idno type="wicri:Area/Ncbi/Merge">000A61</idno><idno type="wicri:Area/Ncbi/Curation">000A61</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A61</idno><idno type="wicri:Area/Main/Merge">000379</idno><idno type="wicri:Area/Main/Curation">000379</idno><idno type="wicri:Area/Main/Exploration">000379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Targeting viral entry as a strategy for broad-spectrum antivirals</title><author><name sortKey="Mazzon, Michela" sort="Mazzon, Michela" uniqKey="Mazzon M" first="Michela" last="Mazzon">Michela Mazzon</name><affiliation wicri:level="4"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Marsh, Mark" sort="Marsh, Mark" uniqKey="Marsh M" first="Mark" last="Marsh">Mark Marsh</name><affiliation wicri:level="4"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author></analytic><series><title level="j">F1000Research</title><idno type="eISSN">2046-1402</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marsh, M" uniqKey="Marsh M">M Marsh</name></author><author><name sortKey="Helenius, A" uniqKey="Helenius A">A Helenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercer, J" uniqKey="Mercer J">J Mercer</name></author><author><name sortKey="Schelhaas, M" uniqKey="Schelhaas M">M Schelhaas</name></author><author><name sortKey="Helenius, A" uniqKey="Helenius A">A Helenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez San Martin, C" uniqKey="Sanchez San Martin C">C Sánchez-San Martín</name></author><author><name sortKey="Liu, Cy" uniqKey="Liu C">CY Liu</name></author><author><name sortKey="Kielian, M" uniqKey="Kielian M">M Kielian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercer, J" 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sortKey="Mazzon, Michela" sort="Mazzon, Michela" uniqKey="Mazzon M" first="Michela" last="Mazzon">Michela Mazzon</name></region><name sortKey="Marsh, Mark" sort="Marsh, Mark" uniqKey="Marsh M" first="Mark" last="Marsh">Mark Marsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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